Objective: To assess the quality of life of people in quarantine and isolation centres in the Rawalpindi Cantonment area. Study Design: Cross-sectional study. Place and Duration of Study: Isolation Centre of Pak Emirates Military Hospital and Armed Forces Institute of Regenerative Medicine Rawalpindi Pakistan and various Quarantine Centres in the Rawalpindi Cantonment area, from Aug 2020 to Mar 2021. Methodology: A total of 187 individuals were included in the study. All participants were requested to fill out the World Health Organization Quality-of-Life Scale (WHOQOL-BREF) Urdu or English version according to their education level and preference. Results: There were 108(57.75%) cases who remained in isolation, and 79(42.25%) cases were from quarantine. Quarantined individuals reported significant reduction not only in total score (p