Background Since the outbreak of COVID-19 infection, community medical personnel on the front lines of prevention and control of COVID-19 face the risk of direct contact with the virus, as well as problems such as high-intensity work, long working hours and high psychological pressure. Therefore, it is of great significance to explore the mental health status of community medical personnel and its internal relationship for the tailored implementation of mental health interventions. Objective To understand the mental health status of community medical personnel during the normalized prevention and control of COVID-19 and explore its influencing factors. Methods A total of 296 cases of community medical personnel in Zhongshan City were selected as the study subjects on December 2021 using a multi-stage random sampling method. The general information questionnaire, self-designed questionnaire of working pressure on COVID-19 prevention and control among community medical personnel, Generalized Anxiety Disorder 7 (GAD-7) and Patient Health Questionnaire 9 (PHQ-9) were administered for online investigation, and multivariate Logistic regression analysis was performed to explore the influencing factors of the perceived stress level on COVID-19 prevention and control, the presence of anxiety and depression of community medical personnel. Results Among the community medical personnel in Zhongshan City, the detection rate of high perceived working pressure on COVID-19 prevention and control was 10.1% (30/296) . The prevalence of anxiety and depression at moderate level was 7.1% (21/296) and 9.5% (28/296) , respectively. Gender, the existence of depression and the level of perceived working pressure on COVID-19 prevention and control were influencing factors of the presence of anxiety among community medical personnel (P