Purpose: To compare the quantitative data of multiparametric prostatic MRI with Gleason scores of histopathological analysis. Materials and methods: One hundred twenty-two patients performed Multiparametric MRI of the prostate. Functional MRI quantitative data (including diffusion with mean ADC value and spectroscopic metabolic ratio) where the DWI is employing b 50, 400, 800, 1000 and 2000 sec/mm2 and multivoxel MR spectroscopy compared with of Gleason scores of histopathological results. Malignant cases are classified into three groups according to their Gleason score as group I with Gleason score â¤6, group II Gleason score 7, while Gleason score 8â10 stratified as Group III. Results: The histopathological analysis reveals 78 malignant cases and 44 benign Cases. The significant statistical difference between group I and the other two groups (pÂ