The 7050 alloy is a kind of Al-Zn-Mg-Cu alloy that is widely used for aircraft structures. Although the deformation behavior of the solid solution state 7050 aluminum alloy is critical for engineering and manufacturing design, it has received little attention. In this study, the room and warm compression behavior of the solid solution-state 7050 alloy was researched, and a modified model with variable parameters was built for the flow stress and load prediction. The isothermal compression tests of the solid solution-state 7050 alloy were performed under the conditions of a deformation temperature of 333–523 K, a strain rate of 10−3–10−1 s−1, and a total reduction of 50%. The strain-stress curves at different temperatures were corrected by considering interface friction. The flow stress model of aluminum was established using the modified Voce model. For evaluating the modified Voce model’s prediction accuracy, the flow stresses calculated by the model were compared with the experimental values. Consequently, for assessing its prediction abilities in finite element applications, the whole compression process was simulated in the finite element analysis platform. The results sufficiently illustrated that the modified Voce-type model can precisely predict the complex flow behaviors during warm compression. This study will guide the prediction of the warm compression load and the optimization of the heat treatment process of the alloy.