The role of Nrf2 in the secondary brain injury after intracerebral hemorrhage
- Resource Type
- article
- Authors
- XU Wei; XIE Zhi⁃yi; WANG Ze⁃xu; MA Lu; YOU Chao; HU Xin
- Source
- Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 22, Iss 10, Pp 836-840 (2022)
- Subject
- nuclear factor ⁃ erythroid 2 ⁃ related factor 2 (not in mesh)
cerebral hemorrhage
brain injuries
oxidative stress
reveiw
Neurology. Diseases of the nervous system
RC346-429
- Language
- English
Chinese
- ISSN
- 1672-6731
Currently, there is still a lack of effective treatment options for intracerebral hemorrhage (ICH). It remains crucial to explore treatment to alleviate the secondary brain injury after ICH and improve the prognosis. Nuclear factor ⁃erythroid 2⁃related factor 2 (Nrf2) is the key transcriptional factor during oxidative stress. It also plays an important role in the secondary injury after ICH. This article reviews the regulatory mechanism of Nrf2 and its protective role in the secondary brain injury after ICH, to explore its possibility as a therapentic target.