Amelioration of Hepatic Steatosis by the Androgen Receptor Inhibitor EPI-001 in Mice and Human Hepatic Cells Is Associated with the Inhibition of CYP2E1
- Resource Type
- article
- Authors
- Shuqin Wang; Xue Li; Weizhe Xu; Jing Gao; Yin Wang; Xiaoyuan Jia; Gongchu Li; Qiuwei Pan; Kan Chen
- Source
- International Journal of Molecular Sciences, Vol 23, Iss 24, p 16063 (2022)
- Subject
- hepatic steatosis
CYP2E1
EPI-001
NAFLD
Biology (General)
QH301-705.5
Chemistry
QD1-999
- Language
- English
- ISSN
- 1422-0067
1661-6596
Nonalcoholic fatty liver disease (NAFLD) is recognized as a metabolic disease characterized by hepatic steatosis. Despite the growing burden of NAFLD, approved pharmacological treatment is lacking. As an inhibitor of androgen receptor (AR), EPI-001 is being explored for the treatment of prostate cancer. This study aimed to investigate the potential of EPI-001 for treating NAFLD in free fatty acids (FFAs)-induced human hepatic cells and high-fat-high-sugar (HFHS)-feeding mice. Our results showed that EPI-001 reduced lipid accumulation in hepatic cells and ameliorated hepatic steatosis in mouse livers. Further exploration suggested that the effect of EPI-001 was associated with CYP2E1-mediated reduction of reactive oxygen species (ROS). This provides encouraging evidence for further studies on EPI-001 therapy for NAFLD.