Carbohydrate inhibitors of cholera toxin
- Resource Type
- article
- Authors
- Vajinder Kumar; W. Bruce Turnbull
- Source
- Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 484-498 (2018)
- Subject
- carbohydrate
cholera
multivalency
toxin
Science
Organic chemistry
QD241-441
- Language
- English
- ISSN
- 1860-5397
Cholera is a diarrheal disease caused by a protein toxin released by Vibrio cholera in the host’s intestine. The toxin enters intestinal epithelial cells after binding to specific carbohydrates on the cell surface. Over recent years, considerable effort has been invested in developing inhibitors of toxin adhesion that mimic the carbohydrate ligand, with particular emphasis on exploiting the multivalency of the toxin to enhance activity. In this review we introduce the structural features of the toxin that have guided the design of diverse inhibitors and summarise recent developments in the field.