A luciferase prosubstrate and a red bioluminescent calcium indicator for imaging neuronal activity in mice
- Resource Type
- article
- Authors
- Xiaodong Tian; Yiyu Zhang; Xinyu Li; Ying Xiong; Tianchen Wu; Hui-Wang Ai
- Source
- Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Bioluminescence imaging of neuronal activity is desired. Here the authors report a luciferase prosubstrate activatable in vivo by nonspecific esterase and engineer a bioluminescent indicator with responsiveness to calcium ions: integration of these components enabled imaging of neuronal activity in mice.