Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
- Resource Type
- article
- Authors
- Thomas Daix; Robin Jeannet; Ana Catalina Hernandez Padilla; Philippe Vignon; Jean Feuillard; Bruno François
- Source
- Journal of Intensive Care, Vol 9, Iss 1, Pp 1-5 (2021)
- Subject
- Biomarker
COVID-19
Immature granulocytes
Secondary infections
Ventilator-associated pneumonia
Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
- Language
- English
- ISSN
- 2052-0492
Abstract During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population.