The objective of this paper is to estimate the trend of the Total Ozone Column (TOC) over Togo. A Multi-Sensor Reanalysis-2 (MSR-2) of the TOC over the entire territory of Togo was used. A Multiple Linear Regression (MLR) method has been applied to retrieve the interannual contributions of different forcings and the long-term variability. It was found that the Annual Oscillation (AnO), the Quasi Biennial Oscillation at 30 mb (QBO30), the Solar Flux (SF), and the El Niño–Southern Oscillation (ENSO) has a statistically significant influence on the interannual variability of the TOC. The strongest contribution (22 ± 1.4 DU) is allocated to the AnO while the weakest (