C-Sibelia: an easy-to-use and highly accurate tool for bacterial genome comparison [v1; ref status: indexed, http://f1000r.es/27n]
- Resource Type
- article
- Authors
- Ilya Minkin; Hoa Pham; Ekaterina Starostina; Nikolay Vyahhi; Son Pham
- Source
- F1000Research, Vol 2 (2013)
- Subject
- Bioinformatics
Microbial Evolution & Genomics
Medicine
Science
- Language
- English
- ISSN
- 2046-1402
We present C-Sibelia, a highly accurate and easy-to-use software tool for comparing two closely related bacterial genomes, which can be presented as either finished sequences or fragmented assemblies. C-Sibelia takes as input two FASTA files and produces: (1) a VCF file containing all identified single nucleotide variations and indels; (2) an XMFA file containing alignment information. The software also produces Circos diagrams visualizing high level genomic architecture for rearrangement analyses. C-Sibelia is a part of the Sibelia comparative genomics suite, which is freely available under the GNU GPL v.2 license at http://sourceforge.net/projects/sibelia-bio. C-Sibelia is compatible with Unix-like operating systems. A web-based version of the software is available at http://etool.me/software/csibelia.