The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren’s Syndrome
- Resource Type
- article
- Authors
- Francesca Barone; Joana Campos; Simon Bowman; Benjamin A Fisher
- Source
- Swiss Medical Weekly, Vol 145, Iss 3738 (2015)
- Subject
- histology
Sjögren's syndrome
germinal centers
biologics
outcome measures
Medicine
- Language
- English
- ISSN
- 1424-3997
Primary Sjögren’s syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.