The role of red blood cell distribution width in predicting coronary artery lesions in pediatric patients with kawasaki disease
- Resource Type
- article
- Authors
- Jianghui Cai; Mi Tang; Shuping Shuai; Rui Zhang; Hongxi Zhang; Yanfeng Yang; MengJun Wu; Hua Liang; Shasha Xing
- Source
- Frontiers in Cardiovascular Medicine, Vol 10 (2023)
- Subject
- kawasaki disease
KD
red blood cell distribution
coronary artery lesion
cals
Diseases of the circulatory (Cardiovascular) system
RC666-701
- Language
- English
- ISSN
- 2297-055X
14725843
BackgroundRecent studies have shown that red blood cell distribution width (RDW) has emerged as a novel predictor of cardiovascular diseases. We aim to investigate the association between RDW and the risk of coronary artery lesions (CALs) in pediatric patients with Kawasaki disease (KD).MethodsKD patients were classified as the CALs group (patients with CALs) and non-CALs group (patients without CALs). Differences among the groups were analyzed by Mann-Whitney U-test and Chi-square analysis. The independent risk factors of CALs were identified by multivariate logistic regression analysis, followed by receiver operating characteristic (ROC) curve analysis to calculate the optimal cut-off value.ResultsThe red blood cell distribution width (RDW) and C-reactive protein were significantly higher in the CALs group than those in the non-CALs group (p 13.86%, with a sensitivity of 75.79% and specificity of 92.81% (AUC = 0.869, 95% CI = 0.844–0.892; p 13.86%) may be used as novel biomarkers for early predicting CALs in KD patients during the acute phase.