Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation
- Resource Type
- article
- Authors
- Binbin kang; Dongmei Lan; Chao Yao; Ping Liu; Xiaohong Chen; Shengcai Qi
- Source
- Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
- Subject
- Cu doped
osteogenic differentiation
antibacterials
micro-arc oxidation
TiO2 coating
Biotechnology
TP248.13-248.65
- Language
- English
- ISSN
- 2296-4185
In order to enhance osteogenic differentiation and antibacterial property of dental implants, volcano-shaped microporous TiO2 coatings doped with Cu were fabricated via micro-arc oxidation (MAO) on Ti. Cu-doped coating with different mass ratios of Cu were obtained by changing the concentration of copper acetate in the electrolyte. The structure of Cu-TiO2 coatings were systematically investigated. Element Copper was uniformly distributed throughout the coating. Compared with TiO2 coating, the Cu-doped can further improved proliferation of bone mesenchymal stem cells (BMSCs), facilitated osteogenic differentiation. The bacteriostasis experiments demonstrated that Cu-doped TiO2 coating possess excellent antibacterial property against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis).