Introduction: The frequency of antiretroviral therapy (ART)-induced side effects varies in HIV-infected patients. In this study, we aimed to compare drug-induced side effects developing in patients receiving different ART regimens. Materials and Methods: This study was performed after obtaining approval of İstanbul Kartal Dr. Lütfi Kırdar Training and Research Hospital"s Ethics Committee (89513307/1009/515) on 30.12.2015. Ninety-five patients with HIV infection followed-up between January 2012 and December 2015 who received ART were included in this study. Their clinical and laboratory findings were evaluated retrospectively and possible drug-related side effects were investigated. Antiretroviral therapy regimens were compared using chi-square test and Fisher"s exact test for categorical variables and with Mann-Whitney U test for numerical variables; changes in numerical variables were compared using Wilcoxon test. SPSS 22.0 software (Chicago, IL, USA) was used for data analyses. Results: All cases were treated with regimens consisting of tenofovir/emtricitabine (TDF/FTC). Three patients restarted treatment after quitting for several months, thus 98 regimens administered to 95 patients were evaluated. Forty-nine of them received protease inhibitors (PIs), 44 received integrase inhibitors (INSTIs), and five received non-nucleoside reverse transcriptase inhibitors. The median (IQR) follow-up period was seven (4-13) months. None of the patients had renal function abnormality before ART but during treatment three (3.1%) of them needed renal dose adjustment for TDF/FTC. Compared to baseline values, there were significant differences in creatinine and creatinine clearance levels during treatment (p