Primary intraventricular synovial sarcoma of the brain with recurrence - case presentation
- Resource Type
- article
- Authors
- Anna McCool; Clinton Turner; Sarah Turner; Peter Heppner; Frank Saran
- Source
- BMC Neurology, Vol 22, Iss 1, Pp 1-6 (2022)
- Subject
- Case report
Neuro-oncology
Synovial sarcoma
Neurology. Diseases of the nervous system
RC346-429
- Language
- English
- ISSN
- 1471-2377
Abstract Background We report a case of recurrent primary intraventricular synovial sarcoma of the brain with no extracranial primary, initially reported as a haemangiopericytoma. We believe this is the first reported case of primary intraventricular synovial sarcoma at this site. Case presentation A 27-year-old male presented to hospital with a new onset of seizures. Imaging revealed a left ventricular trigone mass with surrounding oedema. He underwent a left occipito-temporal craniotomy and resection with the histology reported as haemangiopericytoma. Resection was followed by adjuvant radiation treatment. Seven years later follow-up imaging revealed a 4 mm contrast enhancing lesion in the previous surgical bed. The patient underwent resection. Histological analysis of the recurrence revealed a spindle cell tumour with a SS18 gene rearrangement consistent with synovial sarcoma. Retrospective fluorescent in-situ hybridisation analysis of original histology also revealed a SS18 gene rearrangement consistent with a diagnosis of synovial sarcoma. Conclusion Synovial sarcoma should be included as part of the differential diagnosis for patients presenting with intraventricular spindle cell tumours in the brain.