Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria
- Resource Type
- article
- Authors
- Sehwan Jang; Xavier R. Chapa-Dubocq; Silvia Fossati; Sabzali Javadov
- Source
- Frontiers in Physiology, Vol 12 (2021)
- Subject
- permeabilized cells
mitochondria
calcium retention capacity
permeability transition pore
mitochondrial swelling
Physiology
QP1-981
- Language
- English
- ISSN
- 1664-042X
In response to various pathological stimuli, such as oxidative and energy stress accompanied by high Ca2+, mitochondria undergo permeability transition (PT) leading to the opening of the non-selective PT pores (PTP) in the inner mitochondrial membrane. Opening of the pores at high conductance allows the passage of ions and solutes