The effect of histo-blood group ABO system transferase (BGAT) on pregnancy related outcomes:A Mendelian randomization study
- Resource Type
- article
- Authors
- Yuqi Sun; Haonan Zheng; Manqing Wang; Rongrong Gu; Xueyan Wu; Qian Yang; Huiling Zhao; Yufang Bi; Jie Zheng
- Source
- Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2067-2075 (2024)
- Subject
- Mendelian randomization
ABO
BGAT
venous complication in pregnancy
gestational hypertension
Biotechnology
TP248.13-248.65
- Language
- English
- ISSN
- 2001-0370
Protein level of Histo-Blood Group ABO System Transferase (BGAT) has been reported to be associated with cardiometabolic diseases. But its effect on pregnancy related outcomes still remains unclear. Here we conducted a two-sample Mendelian randomization (MR) study to ascertain the putative causal roles of protein levels of BGAT in pregnancy related outcomes. Cis-acting protein quantitative trait loci (pQTLs) robustly associated with protein level of BGAT (P