Objective(s): The "pre-marriage education program" is one of the strategies to strengthen the family foundation in Iran. The present study was carried out with the support of the Iran Ministry of Health and Medical Education to evaluate this program. This paper presents the results obtained on knowledge and satisfaction of couples. Methods: This was an interventional study on a sample of couples participating in a pre-marriage education program. The intervention was offered via in-person and virtual (online and offline) aproaches. Ninety-six centers of pre-marriage education through country were selected by simple random sampling. A convince sample of 15 couples (15 men and 15 women) was thought for each center. Data was collected by two questionnaires and analyzed using the SPSS-18 software. Results: A total of 2868 people were entered into the study. Pre-marriage education led to an increase in knowledge. The mean score of knowledge changed from 8.78 (SD = 1.693) to 9.34 (SD = 1.639) (P