Objective: To determine the bacteriology of COPD exacerbations in hospitalized patients of our institute, assessment of antibiogram and correlation of clinical and investigative profiles of patients. Design: 160 hospitalized and clinically diagnosed cases of AECOPD were evaluated for clinical characteristics, sputum bacteriology and antibiogram. Results: Sputum culture positivity was observed in 78 cases (48.7%). S. pneumoniae (13%) was the most common organism isolated. However collectively, gram negative bacteria (GNB) were the predominant etiological agent (35.7%). Among GNB, E. coli (9.4%) was the most common isolated organism followed by Acinetobacter (8.1%), P. aeruginosa (7.5%) and Klebsiella (6.3%). Spo2