Abstract Mental health disorders are linked to systemic inflammation. Due to high inflammation and mental health disorders in COVID‐19 patients, we aimed to investigate the relationship between blood inflammatory markers such as red cell distribution width to platelet ratio (RPR), platelet‐lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), red cell distribution width (RDW), white blood cell (WBC), and psychological function in COVID‐19 patients. In the current cross‐sectional study, neuro‐psychological function, and a complete blood count (CBC) were measured on 120 COVID‐19 patients aged >30 years from the Imam Reza Hospital in Mashhad, Iran. Our results showed that anxiety related to MCHC (mean ± SD: 32.71 ± 1.68, p