Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
- Resource Type
- article
- Authors
- Vanni Caruso; Mariachiara Zuccarini; Patrizia Di Iorio; Ishaq Muhammad; Maurizio Ronci
- Source
- Frontiers in Pharmacology, Vol 12 (2021)
- Subject
- purinergic receptors
food intake
metabolic homeostasis
orexigen and anorexigen neurons
obesity
Therapeutics. Pharmacology
RM1-950
- Language
- English
- ISSN
- 1663-9812
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.