Expression of PD-L1 and p-RPS6 in epithelial dysplasia and squamous cell carcinoma of the oral cavity
- Resource Type
- article
- Authors
- Jaruwat Hanroongsri; Panomwat Amornphimoltham; Rania H. Younis; Risa Chaisuparat
- Source
- Frontiers in Oral Health, Vol 5 (2024)
- Subject
- oral epithelial dysplasia
oral squamous cell carcinoma
PD-L1
RPS6
malignant transformation
Dentistry
RK1-715
- Language
- English
- ISSN
- 2673-4842
IntroductionOral squamous cell carcinoma (OSCC) is often preceded by oral epithelial dysplasia (OED). The role of ribosomal protein S6 (RPS6) and programmed cell death ligand-1 (PD-L1) in the progression of OED to OSCC remains unclear. This study aimed to investigate the expression of phosphorylated RPS6 (p-RPS6) and PD-L1 in OSCC and OED and to examine its relationship with clinicopathological features.MethodsFifty-two OSCC and 48 OED cases were recruited for immunohistochemical analysis of p-RPS6 and PD-L1 expression. The expression of markers was correlated with clinicopathological features of OSCC and OED.ResultsWe found p-RPS6 expression in all cases of OSCC and OED, whereas PD-L1 was expressed in 42/48 (87%) OED and in 28/52 (53%) OSCC. The patients with mild OED presented higher expression level of PD-L1 and p-RPS6 significantly, when compared to moderate-differentiated OSCC patients (p