Objectives: Drugs opposing the effect of vascular endothelial growth factor (anti-VEGF) inhibit angiogenesis slowing down and eventually stopping solid tumors growth. Nevertheless these drugs can cause hypertension (that seems to be correlated with cancer outcome) and cardiac dysfunction. We hypnotize there is a correlation between the early stiffening of cardiovascular system and the drug effectiveness. For this purpose we analyzed the short term changes in cardiovascular structure and function in patients treated with antiVEGF drugs. Methods: We enrolled 20 patients suffering from metastatic cancer (17 renal, 2 thyroid and 1 GIST), age 64±11 years (mean±SD). We measured blood pressures (BPs), cardiac and vascular parameters at baseline (B) and after two weeks of treatment (T1) (transthoracic echocardiography with 2D strain evaluation, cf-PWV, Aix). Results: At B our population showed normal BPs (mean±SD:121±17/69±9.5mmHg) and systolic function (EF: 59%,). Global longitudinal strain (GLS) was −21±3%, cf PWV was 12.1±3.3m/sec and Aix was 0.24±0,08%. At T1 we observed a significant increase in BPs (137±16/83±10mmHg, p