Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma
- Resource Type
- article
- Authors
- Filipa Ferreira da Silva; Rita Barata; Inês Rolim; Catarina Carvalheiro; Nuno Gil; Marcos Pantarotto
- Source
- Frontiers in Oncology, Vol 12 (2022)
- Subject
- choriocarcinoma
lung neoplasms
primary tumor
non-gestational trophoblastic disease
human chorionic gonadotropin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2234-943X
Gestational trophoblastic neoplasias (GTN) are malignant neoplasms that occur in pregnant or recently pregnant women. Choriocarcinoma (CCA) is a highly aggressive and rare GTN, and cases outside the female genital tract are commonly seen as secondary manifestations of gynecologic disease. In this paper, we describe the case of a 40 years-old female patient with a primary pulmonary CCA who was surgically treated and for whom the confirmation of the primary origin of the tumor was possible using a DNA short tandem repeat genotyping. Distinction between gestational and non-gestational trophoblastic neoplasia is crucial as they require different therapeutic approach and have different prognoses.