We examined the effects of Enalapril on glomerular and tubular renal changes induced by Gentamicin. The control group of Wistar rats was treated by physiological solvent. The second group was treated with Gentamicin in the dose of 100 mg/kg b.m. The third group was treated with Gentamicin in the same dose and with Enalapril in the dose of 1 mg/kg b.m. The levels of sodium, potassium, urea and creatinine from the blood samples were analyzed. The kidneys were taken out and processed in a standard histological way, by haematoxilin eosin and periodic acid shift coloring for light microscopy. Our results showed that simultaneous treatment with Gentamicin and Enalapril intensified and extensified the nephron morphological changes which corresponded to biochemical changes. The decrease of sodium serum concentration (p