Molecular basis of pathogenic parasitic infections: insights from parasite kinome
- Resource Type
- article
- Authors
- Sheeza Khan; Rishabh Kaushik; Meesha Sharma; Neha Raina; Faizan Ahmad; Asimul Islam
- Source
- Frontiers in Bioscience-Landmark, Vol 25, Iss 8, Pp 1488-1509 (2020)
- Subject
- protein kinase
pathogenesis
mycobacterium
plasmodium
streptococcus
leishmania
cryptococcus
magnaporthe
ustilago
review
Biochemistry
QD415-436
Biology (General)
QH301-705.5
- Language
- English
- ISSN
- 2768-6701
Infectious diseases caused by numerous parasitic pathogens represent a global health conundrum. Several animal and plant pathogens are responsible for causing acute illness in humans and deadly plant infections. These pathogens have evolved a diverse array of infection strategies and survival methods within the host organism. Recent research has highlighted the role of protein kinases in the overall virulence and pathogenicity of the pathogens. Protein kinases (Pks) are a group of enzymes known to catalyse the phosphorylation of a wide variety of cellular substrates involved in different signalling cascades. They are also involved in regulating pathogen life cycle and infectivity. In this review, we attempt to address the role of parasite kinome in host infection, pathogen survival within the host tissue and thereby disease manifestation. The understanding of the parasite kinome can be a potential target for robust diagnosis and effective therapeutics.