Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis
- Resource Type
- article
- Authors
- Takeshi Yamaura; Tatsuhiko Kasaoka; Naoko Iijima; Masaaki Kimura; Shinji Hatakeyama
- Source
- BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019)
- Subject
- Atherosclerosis
Focal adhesion kinase
apoE KO
LDLr KO
Medicine
Biology (General)
QH301-705.5
Science (General)
Q1-390
- Language
- English
- ISSN
- 1756-0500
Abstract Objective Therapeutic effects of focal adhesion kinase (FAK) inhibition using a small molecule inhibitor was evaluated in apolipoprotein E (apoE) knockout (KO) and low-density lipoprotein receptor (LDLr) KO mouse atherosclerosis models. Results The prevention trial consisted of an 8-week treatment with an FAK inhibitor concurrent treatment with a high fat (HF)/high cholesterol (HC) diet. The intervention trial consisted of 6- and 8-week treatment after 6- and 8-week pre-loading, respectively, of a HF/HC diet in apoE KO and LDLr KO mice, respectively. The inhibitor was admixed with a HF/HC diet and mice were given free access to the admixture. The FAK inhibitor exhibited marked inhibition against the development of the atherosclerosis in both of prevention and intervention trials at a dose of 0.03% without showing any remarkable toxic properties in biochemical examinations. These results indicated that FAK inhibition might be a possible candidate for novel therapeutic targets against atherosclerosis.