Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
- Resource Type
- article
- Authors
- Mansour Moghimi; Forough Tavakoli; Masoud Doosti; Abbas Ahmadi-Vasmehjani; Mohsen Akhondi-Meybodi
- Source
- BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019)
- Subject
- Polymorphism
Hepatitis C
IL-28B genotype
Yazd
Medicine
Biology (General)
QH301-705.5
Science (General)
Q1-390
- Language
- English
- ISSN
- 1756-0500
Abstract Objectives Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. Result The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003).