Can high-dose tranexamic acid have a role during transurethral resection of the prostate in large prostates? A randomised controlled trial
- Resource Type
- article
- Authors
- Mohamed Samir; Ahmed M. Saafan; Rania M. Afifi; Ahmed Tawfick
- Source
- Arab Journal of Urology, Vol 20, Iss 1, Pp 24-29 (2022)
- Subject
- benign prostatic hyperplasia
haemorrhage
high-dose tranexamic acid
transurethral resection of prostate
Diseases of the genitourinary system. Urology
RC870-923
- Language
- English
- ISSN
- 2090-598X
2090598X
Objectives To assess the efficacy and safety of high-dose tranexamic acid (TXA) during bipolar transurethral resection of the prostate (B-TURP) in patients with large prostates compared to placebo. Patients and methods From February 2018 to May 2020, 204 patients with enlarged prostates of 80–130 g and in need of surgical intervention were randomised into two groups. Patients in Group A underwent B-TURP and received TXA as an intravenous loading dose of 50 mg/kg over 20 min before induction of anaesthesia followed by a maintenance infusion of 5 mg/kg/h until resection was completed. The patients in Group B (placebo) received a saline infusion of a similar volume. Results There was highly significant drop in haemoglobin in the placebo group at 4- and 24-h postoperatively compared with the TXA group (P