Tumor growth fueled by spurious senescence phenotypes
- Resource Type
- article
- Authors
- Michalis Mastri; John M. L. Ebos
- Source
- Molecular & Cellular Oncology, Vol 6, Iss 2, Pp 1-3 (2019)
- Subject
- angiogenesis
resistance
senescence
vegfr tki
rebound
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2372-3556
23723556
Cancer treatments can induce a form of senescence that halts cellular division while allowing continued secretion of tumor-promoting proteins. We recently found that antiangiogenic treatment resistance can lead to a transient hijacking of the senescence-controlled secretory machinery that, when therapeutically targeted during treatment cessation, can blunt rebound tumor growth.