Increase of EEG spectral theta power indicates higher risk of the development of severe cognitive decline in Parkinson’s disease after 3 years
- Resource Type
- article
- Authors
- Vitalii V Cozac; Menorca Chaturvedi; Florian Hatz; Antonia Meyer; Peter Fuhr; Ute Gschwandtner
- Source
- Frontiers in Aging Neuroscience, Vol 8 (2016)
- Subject
- EEG
Parkinson's disease
cognitive decline
cohort study
Cognitive tests
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
- Language
- English
- ISSN
- 1663-4365
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson’s disease.Methods: We prospectively investigated 37 patients with Parkinson’s disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables (global relative median power spectra) were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration.Results: The following baseline parameters significantly predicted severe cognitive decline: global relative median power theta (4-8 Hz), cognitive task performance in executive functions and working memory.Conclusions: Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.