Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
- Resource Type
- article
- Authors
- Jian Yin; Steffen Eller; Mayeul Collot; Peter H. Seeberger
- Source
- Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 2067-2071 (2012)
- Subject
- glycosaminoglycans (GAGs)
glycosylation
resins
safety-catch linker
solid-phase synthesis
Science
Organic chemistry
QD241-441
- Language
- English
- ISSN
- 1860-5397
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis.