Membrane trafficking in health and disease
- Resource Type
- article
- Authors
- Rebecca Yarwood; John Hellicar; Philip G. Woodman; Martin Lowe
- Source
- Disease Models & Mechanisms, Vol 13, Iss 4 (2020)
- Subject
- disease
endocytic pathway
genetic disorder
membrane traffic
secretory pathway
vesicle
Medicine
Pathology
RB1-214
- Language
- English
- ISSN
- 1754-8403
1754-8411
Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a Glance article and accompanying poster, we outline the major cellular trafficking pathways and discuss how defects in the function of the molecular machinery that mediates this transport lead to various diseases in humans. We also briefly discuss possible therapeutic approaches that may be used in the future treatment of trafficking-based disorders.