Water is a vulnerable resource in the Mediterranean region, but irrigation demands have been increasing to mitigate effects of environmental stress. Sustainable wine production involves the precise use of water in the vineyard and winery. Improved knowledge on grapevine ecophysiology and genetics, the use of sensors for soil and canopy monitoring, plant phenotyping and improved crop management can help save water. In the winery, best management practices and improved water metrics will promote water savings and decrease wastewater production.