Abstract The advanced molybdenum-based rare process experiment (AMoRE) aims to search for neutrinoless double beta decay ($$0\nu \beta \beta $$ 0νββ ) of $$^{100}$$ 100 Mo with $$\sim 100\,\hbox {kg}$$ ∼100kg of $$^{100}$$ 100 Mo-enriched molybdenum embedded in cryogenic detectors with a dual heat and light readout. At the current, pilot stage of the AMoRE project we employ six calcium molybdate crystals with a total mass of 1.9 kg, produced from $$^{48}$$ 48 Ca-depleted calcium and $$^{100}$$ 100 Mo-enriched molybdenum ($$^{48{{\text {depl}}}}\hbox {Ca}^{100}\hbox {MoO}_{4}$$ 48deplCa100MoO4 ). The simultaneous detection of heat (phonon) and scintillation (photon) signals is realized with high resolution metallic magnetic calorimeter sensors that operate at milli-Kelvin temperatures. This stage of the project is carried out in the Yangyang underground laboratory at a depth of 700 m. We report first results from the AMoRE-Pilot $$0\nu \beta \beta $$ 0νββ search with a 111 kg day live exposure of $$^{48{{\text {depl}}}}\hbox {Ca}^{100}\hbox {MoO}_{4}$$ 48deplCa100MoO4 crystals. No evidence for $$0\nu \beta \beta $$ 0νββ decay of $$^{100}$$ 100 Mo is found, and a upper limit is set for the half-life of $$0\nu \beta \beta $$ 0νββ of $$^{100}$$ 100 Mo of $$T^{0\nu }_{1/2} > 9.5\times 10^{22}~\hbox {years}$$ T1/20ν>9.5×1022years at 90% C.L. This limit corresponds to an effective Majorana neutrino mass limit in the range $$\langle m_{\beta \beta }\rangle \le (1.2-2.1)\,\hbox {eV}$$ ⟨mββ⟩≤(1.2-2.1)eV .