Visible-light-mediated sulfonylation of anilines with sulfonyl fluorides
- Resource Type
- article
- Authors
- Xin-Qing Li; Qian-Qian Liao; Jun Lai; Yuan-Yue Liao
- Source
- Frontiers in Chemistry, Vol 11 (2023)
- Subject
- sulfonylation
photoredox
radical
sulfonyl fluoride
aniline
Chemistry
QD1-999
- Language
- English
- ISSN
- 2296-2646
Sulfonylaniline motif plays an important role in pharmaceutical sciences. Developed methods towards this structure are typically lack of good modifiability and stability. In this study, visible-light-mediated sulfonylation of aniline using sulfonyl fluoride as a modifiable and stable sulfonylation reagent is described. A variety of substituted sulfonylanilines were synthesized under mild reaction conditions with moderate to good efficiency. The example of late-stage sulfonylation highlighted the advantage of using sulfonyl fluoride as a sulfonylation reagent. In addition, the crucial influence of counterions on the photocatalyst observed in this system would inspire further research on the photochemistry of sulfonyl fluoride.