This study aims to address the gap in the Natural Flood Management (NFM) evidence base concerning its implementation potential in groundwater-dominated catchments. We generated a typology of 198 chalk catchments using redundancy analysis and hierarchical clustering. Three catchment typologies were identified: (1) large catchments, (2) headwater catchments with permeable soils, and (3) catchments with impermeable soils and surfaces (urban and suburban land uses). The literature suggests that natural flood management application is most effective for catchments 2, reducing the likelihood of significant flood mitigation in large catchments. The relatively lower proportion of surface runoff and higher recharge in permeable catchments diminishes natural flood management’s likely efficacy. Impermeable catchments are most suited to natural flood management due to a wide variety of flow pathways, making the full suite of natural flood management interventions applicable. Detailed groundwater flood maps and hydrological models are required to identify catchments where NFM can be used in a targeted manner to de-synchronise sub-catchment flood waves or to intercept runoff generated via groundwater emergence. Whilst our analysis suggests that most chalk groundwater-dominated catchments in this sample are unlikely to benefit from significant flood reductions due to natural flood management, the positive impact on ecosystem services and biodiversity makes it an attractive proposition.