Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism
- Resource Type
- article
- Authors
- Jiongyi Yan; Yinyi Feng; Xuewan Fang; Xiaojuan Cui; Xing Xia; Fang Li; Weisheng Luo; Jianqin Liang; Jianfang Feng; Kai Yu
- Source
- Pharmaceutical Biology, Vol 60, Iss 1, Pp 1264-1277 (2022)
- Subject
- 9-Cis-retinoic acid
iTRAQ
liver disease
RXRα
traditional Chinese medicine
Therapeutics. Pharmacology
RM1-950
- Language
- English
- ISSN
- 13880209
1744-5116
1388-0209
10332626
Context The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear.Objective This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL).Materials and methods Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology.Results Significant anti-LF effects were observed in the high-TFL-dose group (TFL-H, p