Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration
- Resource Type
- article
- Authors
- Kengo Iwasaki; Yihao Peng; Ryuhei Kanda; Makoto Umeda; Isao Ishikawa
- Source
- International Journal of Molecular Sciences, Vol 23, Iss 3, p 1011 (2022)
- Subject
- periodontal disease
regeneration
cell transplantation
conditioned medium
exosome
Biology (General)
QH301-705.5
Chemistry
QD1-999
- Language
- English
- ISSN
- 1422-0067
1661-6596
Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed.