Osteoporosis and periodontitis have as a major characteristics the bone resorption as well as the fact that it affects the adult population. The aim of the study was to assess periodontal status in a group of patients diagnosed with osteoporosis with and without bisphosphonate treatment. Material and Methods: A retrospective study was performed on 63 patients, mean age 64.49 ± 9,362. The necessary data regarding the presence of systemic diseases as well as the oral health of the patient were collected retrospectively from the observation chart, which contains information on demographic data and the clinical exam was performed using the EGOHID The ANOVA and Chi-square test was used to determine the statistical significance and the statistical significance threshold was set at p