Recent advances in carbocupration of α-heterosubstituted alkynes
- Resource Type
- article
- Authors
- Ahmad Basheer; Ilan Marek
- Source
- Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 77 (2010)
- Subject
- alkynes
carbocupration
enamides
regioselectivity
stereoselectivity
syn-addition
vinylcopper
ynamides
ynol ether
Science
Organic chemistry
QD241-441
- Language
- English
- ISSN
- 1860-5397
Carbocupration of α-heterosubstituted alkynes leads to the formation of stereodefined functionalized vinyl copper species as single isomer. Recent advances in the field show that a simple pre-association of the organometallic derivative with an additional polar functional group in the vicinity of the reaction center may completely change the stereochemical outcome of the reaction. Representative examples are given in this mini-review.