PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis
- Resource Type
- article
- Authors
- Áurea Lima; Hugo Sousa; Rui Medeiros; Amanda Nobre; Manuela Machado
- Source
- Discover Oncology, Vol 13, Iss 1, Pp 1-19 (2022)
- Subject
- Gastric cancer
PD-L1
EBV
Microsatellite instability
Immunotherapy
GCLS
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2730-6011
Abstract Objectives The aim of this systematic review and meta-analysis is to the summarize the evidence on programmed cell death protein ligand 1 (PD-L1) in Epstein-Barr virus associated gastric cancer (EBVaGC) and to estimate the expression rate of PD-L1 among this subtype of Gastric Cancer (GC). Materials and methods For this study, PubMed®, EMBASE® and Web of Science® databases were searched for articles published until 1st November 2021. A total of 43 eligible publications with a total of 11,327 patients were included analysis based on inclusion and exclusion criteria. A total of 41 publications present data for proportion estimation and 33 for comparison of PD-L1 between EBV positive and negative GC. DerSimonian-Laird random-effects model was used for meta-analysis. Results The analysis showed that in EBVaGC the pooled positivity rate for PD-L1 was 54.6% (p