Purpose: The evaluation of long-term results of punctal plugs applied to dry eye patients and the potential problems they may bring about. Material and Method: In this study, we retrospectively assessed 30 eyes of 15 patients with moderate to advanced dry eyes who were applied punctal plug (5 mm) for treatment purpose and were observed for 12 months. The patients’ Ocular Surface Disease Index (OSDI ) scoring, Schimer-1 test (without topical anesthesia), tear film break-up time (TBUT) and ocular surface staining with fluorescein results were evaluated and compared before and after 6- and 12-month use of punctal plug. The patients were started on topical antiinflammatory treatment and artificial tears two months before the application of the punctum plug. Results: The patients’ average age was 56.4±2.3 (range: 36-70) years, and the average follow-up period was 15 (12-30) months. The average OSDI score was statistically significantly decreased at 6 and 12 months when compared to the initial value (p