Whole-Blood MicroRNA Sequence Profiling and Identification of Specific miR-21 for Adolescents With Postural Tachycardia Syndrome
- Resource Type
- article
- Authors
- Jing Lin; Jie Shen; Juan Liu; Wenjie Cheng; Lintian Li; Fuyong Jiao
- Source
- Frontiers in Neuroscience, Vol 16 (2022)
- Subject
- postural tachycardia syndrome
whole blood
high-throughput sequencing
miR-21
adolescents
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
- Language
- English
- ISSN
- 1662-453X
ObjectiveThe aim of the study was to establish whether whole-blood microRNA (miRNA) profiles differ between postural tachycardia syndrome (POTS) sufferers and control subjects and to identify the miRNA that regulates plasma H2S.Study DesignHigh-throughput sequencing was used to obtain whole-blood miRNA expression profiles for 20 POTS sufferers and 20 normal children.The thresholds for defining differentially expressed miRNAs (DEmiRNAs) were an adjusted DESeq P of