Preliminary evidence that lectins in infant soy formula apparently bind bovine milk exosomes and prevent their absorption in healthy adults
- Resource Type
- article
- Authors
- Ezra Mutai; Alice Kah Hui Ngu; Janos Zempleni
- Source
- BMC Nutrition, Vol 8, Iss 1, Pp 1-6 (2022)
- Subject
- Bioavailability
Bovine milk exosomes
Human
Infant soy formula
Lectins
microRNA
Nutrition. Foods and food supply
TX341-641
Food processing and manufacture
TP368-456
Medicine (General)
R5-920
- Language
- English
- ISSN
- 2055-0928
Abstract Background Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities and impaired gut health in juvenile mice. Adverse effects of formula feeding may be compounded by using soy formulas due to exosome binding by abundant lectins in that matrix. The purpose of this study was to assess the bioavailability of milk exosomes and their miR cargos added to soy formula in adults, as well as the potential role of soy lectins in exosome bioavailability. Methods Eleven healthy adults (6 men, 5 women) enrolled in this randomized crossover study. Participants consumed 1.0 l of soy formula without (SF) or with (SFE) bovine milk exosomes added. Concentration-time curves of six plasma miRs were analyzed using reverse transcription quantitative PCR. Lectin affinity chromatography was used to assess the binding of exosomes by soy lectins. Data were analyzed by using paired t test. P