Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series
- Resource Type
- article
- Authors
- James B. Doub; Emily L. Heil; Afua Ntem-Mensah; Renaldo Neeley; Patrick R. Ching
- Source
- Antibiotics, Vol 9, Iss 6, p 326 (2020)
- Subject
- biofilms
rifabutin
Staphylococcus
drug interactions
periprosthetic joint infection
Therapeutics. Pharmacology
RM1-950
- Language
- English
- ISSN
- 2079-6382
This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side effects. As well, no patients had recurrence of their staphylococcal infections. This case series shows that rifabutin can be a beneficial adjuvant therapy in Staphylococcus biofilm infections when drug–drug interactions limit the use of rifampin.