Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis
- Resource Type
- article
- Authors
- Yuanlong Li; Qingqiang Tu; Dongmei Xie; Shurui Chen; Kai Gao; Xiaochun Xu; Ziji Zhang; Xifan Mei
- Source
- Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-20 (2022)
- Subject
- Osteoarthritis
Biomimetic nanoparticles
CD90+ MCSs-derived micro-vesicle
Cartilage regeneration
Anti-inflammatory
Biotechnology
TP248.13-248.65
Medical technology
R855-855.5
- Language
- English
- ISSN
- 1477-3155
Highlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis. T-CD90@NPs regulate the polarization of type 2 macrophages to resist inflammation. T-CD90@NPs promote chondrocyte regeneration through the FOXO signaling pathway.