Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids
- Resource Type
- article
- Authors
- Mingfeng Yu; Joseph K.-H. Wong; Cyril Tang; Peter Turner; Matthew H. Todd; Peter J. Rutledge
- Source
- Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 37-41 (2015)
- Subject
- Brønsted acids
click chemistry
deboration
dipyrrins
F-BODIPYs
Science
Organic chemistry
QD241-441
- Language
- English
- ISSN
- 1860-5397
The effective and efficient removal of the BF2 moiety from F-BODIPY derivatives has been achieved using two common Brønsted acids; treatment with trifluoroacetic acid (TFA) or methanolic hydrogen chloride (HCl) followed by work-up with Ambersep® 900 resin (hydroxide form) effects this conversion in near-quantitative yields. Compared to existing methods, these conditions are relatively mild and operationally simple, requiring only reaction at room temperature for six hours (TFA) or overnight (HCl).