Conduction treatment of temporal lobe epilepsy in rats: the dose-effect relationship between current resistance and therapeutic effect
- Resource Type
- article
- Authors
- Shaohui Zhang; Liu Yuan; Chunxiu Liu; Suhui Kuang; Jiaqi Wang; Shuli Liang; Ming Cong
- Source
- Frontiers in Neurology, Vol 14 (2023)
- Subject
- temporal lobe epilepsy (TLE)
current conduction
glutamate
interleukin 1β (IL-1β)
high mobility group protein B1 (HMGB-1)
Neurology. Diseases of the nervous system
RC346-429
- Language
- English
- ISSN
- 1664-2295
ObjectiveTo investigate the effect of current resistance on therapeutic outcomes, and the mechanism of current conduction treatment in a rat model of temporal lobe epilepsy (TLE).MethodsRats were randomly divided into four groups: normal control, epileptic group, low-resistance conduction (LRC) and high-resistance conduction (HRC) group. The content of glutamate (Glu) and gamma-amino butyric acid (GABA) in the hippocampus was determined using a neurotransmitter analyzer. mRNA and protein expression of interleukin 1β (IL-1β) /IL-1 receptor 1(IL-1R1) and high mobility group protein B1 (HMGB-1)/toll-like receptor-4 (TLR-4) in hippocampal neurons were tested. Video electroencephalogram monitoring was used to record seizures and EEG discharges. Cognitive function in the rats was tested using the Morris water maze.ResultsGlu/GABA ratio in the epileptic control and HRC groups was significant differences from LRC group. The levels of HMGB1/TLR4 and IL-1β/IL-1R1 in the LRC group and normal control group were significantly lower than those in epileptic control group (p